Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 13/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24528888 | 0.91 | NR1H2 (0.44) | NR1H2NR1H3GHSRS1PR1KMT2A | |
| SCHEMBL31680225 | 0.89 | GHSR (0.42) | GHSRKMT2ASMN1; SMN2 | |
| SCHEMBL19643138 | 0.89 | GHSR (0.42) | GHSRKMT2ASMN1; SMN2 | |
| SCHEMBL24529088 | 0.88 | HRH3 (0.41) | GHSRKMT2A | |
| SCHEMBL30828033 | 0.88 | HRH3 (0.41) | GHSRKMT2A | |
| SCHEMBL18617674 | 0.86 | GHSR (0.43) | NR1H2NR1H3GHSRKMT2ASMN1; SMN2 | |
| SCHEMBL24528740 | 0.86 | GHSR (0.42) | NR1H2GHSRKMT2ASMN1; SMN2 | |
| SCHEMBL30828046 | 0.86 | GHSR (0.42) | GHSRKMT2A | |
| SCHEMBL24528738 | 0.86 | GHSR (0.42) | GHSRKMT2A | |
| SCHEMBL24528998 | 0.81 | NR1H2 (0.43) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263511-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | Amphista Therapeutics Ltd (GB) | 2023-10-25 | — | — | EP | disclosed |
| CN-116897150-A | Novel bifunctional molecules for protein-targeted degradation | 安菲斯塔治疗有限公司 | 2023-10-17 | — | — | CN | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |