Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 8/20 | 0.53 |
| ▸ | PTGES | O14684 | 4/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529700 | 0.92 | HCRTR2 (0.52) | HCRTR2PTGESAVPR1BROCK2ROCK1 | |
| SCHEMBL27179704 | 0.85 | HCRTR2 (0.73) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL27179703 | 0.85 | HCRTR2 (0.73) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL24529284 | 0.85 | HCRTR2 (0.73) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL24529173 | 0.77 | HCRTR2 (0.72) | HCRTR2PTGESMGLL | |
| SCHEMBL27180582 | 0.77 | HCRTR2 (0.76) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL27180579 | 0.77 | HCRTR2 (0.76) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL24529699 | 0.77 | HCRTR2 (0.72) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL24529470 | 0.77 | HCRTR2 (0.76) | HCRTR2PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL27180862 | 0.77 | HCRTR2 (0.72) | HCRTR2PSEN1PSEN2KCNH2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |