Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529307 | 0.82 | AURKA (0.48) | HCRTR2EPHB4PDPK1AURKASYK | |
| SCHEMBL24529315 | 0.81 | HCRTR2 (0.56) | HCRTR2EPHB4AURKASYK | |
| SCHEMBL24529142 | 0.81 | HCRTR2 (0.46) | HCRTR2EPHB4AURKASYK | |
| SCHEMBL21455694 | 0.80 | BRD4 (0.48) | BRD4EPHB4CCKBR | |
| SCHEMBL24529632 | 0.80 | HCRTR2 (0.56) | HCRTR2EPHB4SYK | |
| SCHEMBL24529671 | 0.80 | HCRTR2 (0.47) | HCRTR2EPHB4AURKASYK | |
| SCHEMBL32663544 | 0.80 | SYK (0.49) | HCRTR2EPHB4AURKASYK | |
| SCHEMBL21439075 | 0.80 | BRD4 (0.49) | BRD4EPHB4PDPK1CCKBR | |
| SCHEMBL24529311 | 0.79 | HCRTR2 (0.45) | HCRTR2EPHB4AURKASYK | |
| SCHEMBL21439422 | 0.79 | BRD4 (0.49) | BRD4EPHB4SYKCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |