Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | CD63 | P08962 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529311 | 0.92 | HCRTR2 (0.45) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL27180200 | 0.90 | HCRTR2 (0.45) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL24529307 | 0.89 | AURKA (0.48) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL24386985 | 0.87 | EPHB4 (0.41) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL24529671 | 0.86 | HCRTR2 (0.47) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL24529335 | 0.84 | AURKA (0.49) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL24529263 | 0.84 | HCRTR2 (0.41) | HCRTR2AURKASYKCD63EPHB4 | |
| SCHEMBL2897650 | 0.81 | SYK (0.73) | SYKCD63 | |
| SCHEMBL24529316 | 0.81 | BRD4 (0.48) | HCRTR2AURKASYKEPHB4 | |
| SCHEMBL24529319 | 0.81 | SYK (0.40) | AURKASYKCD63EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |