SCHEMBL24530076

SCHEMBL24530076

NC(=O)/C=C/c1ccc(Cl)cc1Cl

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.68
ALDH1A1 P00352 3/20 0.68
L3MBTL1 Q9Y468 2/20 0.68
KDM4E B2RXH2 2/20 0.68
GAA P10253 1/20 0.68
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
POLB P06746 1/20 0.58
LMNA P02545 6/20 0.55
KMT2A Q03164 5/20 0.55
MAOB P27338 1/20 0.55
MEN1 O00255 3/20 0.54
CTDSP1 Q9GZU7 1/20 0.54
PTPN5 P54829 1/20 0.52
PKM P14618 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
HTT P42858 1/20 0.50
BACE1 P56817 1/20 0.49
GRIN2D O15399 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8709511 1.00 MAPT (0.68) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL30560948 0.85 MAPT (0.50) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL1193410 0.83 MAPT (0.65) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL165227 0.83 MAPT (0.65) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL29419102 0.83 MAPT (0.65) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL1193408 0.83 MAPT (0.65) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL481451 0.83 MAPT (0.65) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL4849644 0.82 TDP1 (0.57) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL8148557 0.82 MAPT (0.47) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL4608128 0.82 HDAC3 (0.49) MAPTALDH1A1L3MBTL1KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022129953-A1 SARS-COV-2 MPRO INHIBITOR COMPOUNDS HEPTARES THERAPEUTICS LIMITED (GB) 2022-06-23 WO disclosed