SCHEMBL8148557

SCHEMBL8148557

NC(=O)/C=C/c1ccc(F)cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.47
ALDH1A1 P00352 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
BACE1 P56817 2/20 0.46
PELI1 Q96FA3 1/20 0.42
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TTR P02766 1/20 0.40
LMNA P02545 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
MAOB P27338 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8148561 1.00 MAPT (0.47) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL30632999 0.84 TDO2 (0.54) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL6821174 0.84 BACE1 (0.47) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL28448735 0.84 BACE1 (0.47) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL6821176 0.84 BACE1 (0.47) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL1167316 0.84 TDO2 (0.54) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL1167315 0.84 TDO2 (0.54) MAPTALDH1A1L3MBTL1KDM4EGAA
Hydrochloric Acid SCHEMBL6821177 0.83 TDO2 (0.53) MAPTALDH1A1L3MBTL1KDM4EGAA
SCHEMBL5751280 0.82 CYP1A1 (0.55) PELI1CYP1A1CYP1B1
SCHEMBL5751272 0.82 CYP1A1 (0.55) PELI1CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE36625-E Linear and cyclic polymers or oligomers having a photoreactive ethene group ROLIC AG (CH) 2000-03-21 US disclosed
CN-1049224-C Polymers as alignment layer ROLIC AG (CH) 2000-02-09 CN disclosed
US-5539074-A LIQUID CRYSTAL POLYMERS ON SILICA FOR LIGHT SENSITIVE ELEMENTS HOFFMANN-LA ROCHE INC. (US) 1996-07-23 US disclosed
CN-1091458-A Polymkeric substance as oriented layer HOFFMANN LA ROCHE (CH) 1994-08-31 CN disclosed