Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.73 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.73 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | BLK | P51451 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lirafugratinib SCHEMBL30303579 | 0.85 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| Lirafugratinib SCHEMBL22676186 | 0.85 | FGFR1 (1.00) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| Lirafugratinib SCHEMBL29728045 | 0.84 | FGFR1 (0.99) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303773 | 0.83 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676895 | 0.83 | FGFR1 (0.86) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676570 | 0.83 | FGFR1 (0.63) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303887 | 0.83 | FGFR1 (0.63) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676572 | 0.82 | FGFR1 (0.70) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL22676730 | 0.81 | FGFR1 (0.59) | FGFR1FGFR2FGFR4FGFR3CYP3A4 | |
| SCHEMBL30303345 | 0.81 | FGFR1 (0.59) | FGFR1FGFR2FGFR4FGFR3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194946-A1 | FGFR INHIBITORS AND METHODS OF MAKING AND USING THE SAME | RELAY THERAPEUTICS, INC. | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194946-A1 | FGFR INHIBITORS AND METHODS OF MAKING AND USING THE SAME | FGFR3, FGFR2, FGFR1 | FGFR1 3/4885FGFR2 2/4885FGFR4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.