Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21632663 | 0.78 | MC4R (0.43) | PDGFRBKDRMC4R | |
| SCHEMBL21465752 | 0.73 | NR1H2 (0.59) | RETKDM4EALDH1A1POLBNR1H2 | |
| SCHEMBL24533977 | 0.73 | NR1H2 (0.46) | RETKDM4EALDH1A1POLBNR1H2 | |
| SCHEMBL21465801 | 0.71 | KIT (0.48) | BRAFEGFR | |
| SCHEMBL21470482 | 0.71 | GAA (0.48) | RETBRAFEGFR | |
| SCHEMBL24191972 | 0.70 | DDR1 (0.44) | KDM4EALDH1A1POLBNR1H2PDGFRB | |
| SCHEMBL20483488 | 0.69 | KDM4E (0.38) | KDM4EALDH1A1POLBPDGFRBKDR | |
| SCHEMBL30486114 | 0.68 | EGFR (0.46) | RETBRAFEGFR | |
| SCHEMBL25220250 | 0.68 | TSHR (0.39) | ALDH1A1NR1H2PDGFRBKDRMEN1 | |
| SCHEMBL21470484 | 0.68 | FGFR4 (0.41) | RETKDM4EALDH1A1POLBNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022128850-A1 | NOVEL ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES | GALAPAGOS NV (BE) | 2022-06-23 | — | — | WO | disclosed |