Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24535869 | 1.00 | KRAS (0.42) | KRAS | |
| SCHEMBL29680503 | 1.00 | KRAS (0.42) | KRAS | |
| SCHEMBL30868615 | 0.90 | KRAS (0.39) | KRAS | |
| SCHEMBL24535883 | 0.88 | KRAS (0.38) | KRAS | |
| SCHEMBL24536412 | 0.88 | KRAS (0.38) | KRAS | |
| SCHEMBL30706614 | 0.88 | KRAS (0.36) | KRAS | |
| SCHEMBL30707490 | 0.86 | KRAS (0.47) | KRAS | |
| SCHEMBL25253561 | 0.85 | KRAS (0.43) | KRAS | |
| SCHEMBL25253562 | 0.85 | KRAS (0.43) | KRAS | |
| SCHEMBL30430356 | 0.85 | KRAS (0.43) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302162-A | Small molecule inhibitors of KRAS muteins | 默沙东有限责任公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-116829151-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2023097227-A1 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | MERCK SHARP & DOHME LLC (US) | 2023-06-01 | — | — | WO | disclosed |
| WO-2022132200-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |