⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56899 | 0.67 | — | — | |
| SCHEMBL3801704 | 0.65 | — | — | |
| Hydrogen Sulfide SCHEMBL27838627 | 0.64 | — | — | |
| Hydrogen Sulfide SCHEMBL28130279 | 0.64 | — | — | |
| Hydrogen Sulfide SCHEMBL27509537 | 0.64 | — | — | |
| SCHEMBL2174053 | 0.64 | ALDH1A1 (0.53) | — | |
| Phosphine SCHEMBL27276080 | 0.62 | — | — | |
| Hydrogen Sulfide SCHEMBL29184282 | 0.62 | ALDH1A1 (0.63) | — | |
| Hydrochloric Acid SCHEMBL6534749 | 0.61 | HDAC8 (0.44) | — | |
| Iodide SCHEMBL28731796 | 0.61 | HDAC8 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316459-B1 | O-benzyloxime ethers and crop protection agents containing these compounds | BASF AG (DE) | 2001-11-13 | — | — | US | claimed |
| US-5563168-A | FUNGICIDES, INSECTICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1996-10-08 | — | — | US | claimed |
| US-4359327-A | HYDROGEN ELECTRODES, PARACYCLOPHANES | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (FR) | 1982-11-16 | — | — | US | claimed |
| EP-3911640-B1 | PCSK9 INHIBITORS FOR USE IN THERAPY, ESPECIALLY THE TREATMENT OF CARDIOVASCULAR DISEASE | ASTRAZENECA AB (SE) | 2026-05-13 | — | — | EP | disclosed |
| US-12584120-B2 | PCSK9 inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2026-03-24 | — | — | US | disclosed |
| US-20230407285-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | DOGMA THERAPEUTICS, INC. | 2023-12-21 | — | — | US | disclosed |
| US-11603523-B2 | PCSK9 inhibitors and methods of use thereof | ASTRAZENECA AB (SE) | 2023-03-14 | — | — | US | disclosed |
| EP-3911640-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | Astrazeneca AB (SE) | 2021-11-24 | — | — | EP | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |
| US-20200231584-A1 | PCSK9 Inhibitors and Methods of Use Thereof | ASTRAZENECA AB (SE) | 2020-07-23 | — | — | US | disclosed |
| WO-2020150474-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | DOGMA THERAPEUTICS, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
| US-8859543-B2 | Imidazo[1,2-a]pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-14 | — | — | US | disclosed |
| EP-2545055-A1 | IMIDAZO [1, 2 -A]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES | Janssen Pharmaceutica, N.V. (BE) | 2013-01-16 | — | — | EP | disclosed |
| US-20120329792-A1 | IMIDAZO[1,2-a]PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES | JANSSEN PHARMACEUTICA NV | 2012-12-27 | — | — | US | disclosed |
| CN-102791713-A | Imidazo [1,2-A ] pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases | JANSSEN PHARMACEUTICA NV | 2012-11-21 | — | — | CN | disclosed |
| WO-2011110545-A1 | IMIDAZO [1, 2 -A] PYRAZINE DERIVATIVES AND THEIR USE FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-15 | — | — | WO | disclosed |
| EP-1694678-A2 | PROCESS FOR PREPARING HEXAHYDROPYRIMIDO 1,2-A¨AZEPINE-2-CARBOXYLATES AND RELATED COMPOUNDS | Merck & Co., Inc. (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005061501-A2 | PROCESS FOR PREPARING HEXAHYDROPYRIMIDO[1,2-A]AZEPINE-2-CARBOXYLATES AND RELATED COMPOUNDS | MERCK & CO., INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| US-5502187-A | Pharmaceutically active bicyclic-heterocyclic amines | THE UPJOHN COMPANY (US) | 1996-03-26 | — | — | US | disclosed |
| US-4359327-A | HYDROGEN ELECTRODES, PARACYCLOPHANES | AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (FR) | 1982-11-16 | — | — | US | disclosed |