Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.41 |
| ▸ | JAK1 | P23458 | 9/20 | 0.41 |
| ▸ | TYK2 | P29597 | 9/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24539407 | 0.86 | JAK2 (0.45) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24539406 | 0.86 | JAK2 (0.45) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL29732784 | 0.83 | FGFR3 (0.44) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24327398 | 0.82 | JAK2 (0.39) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24327971 | 0.82 | JAK2 (0.39) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL28724036 | 0.81 | JAK2 (0.42) | JAK2JAK1TYK2JAK3RET | |
| SCHEMBL24539477 | 0.81 | JAK2 (0.46) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL29733004 | 0.81 | MAPT (0.42) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24327769 | 0.81 | JAK2 (0.41) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24539588 | 0.79 | JAK2 (0.44) | JAK2JAK1TYK2JAK3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022127753-A1 | FUSED RING AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-06-23 | — | — | WO | disclosed |