SCHEMBL24327971 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	9/20	0.39

▸	JAK1	P23458	9/20	0.39

▸	TYK2	P29597	9/20	0.39

▸	JAK3	P52333	8/20	0.39

▸	RET	P07949	3/20	0.37

▸	CNR1	P21554	1/20	0.37

▸	CNR2	P34972	1/20	0.37

▸	MAPT	P10636	2/20	0.35

▸	TP53	P04637	1/20	0.35

▸	KCNH2	Q12809	2/20	0.35

▸	KDM4E	B2RXH2	1/20	0.34

▸	NPC1	O15118	1/20	0.34

▸	ALDH1A1	P00352	1/20	0.34

▸	GAA	P10253	1/20	0.34

▸	HPGD	P15428	1/20	0.34

▸	RAB9A	P51151	1/20	0.34

▸	SMN1; SMN2	Q16637	1/20	0.34

▸	FGFR3	P22607	1/20	0.34

▸	KDR	P35968	1/20	0.34

▸	PIM1	P11309	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24327326	0.85	JAK2 (0.43)	JAK2JAK1TYK2JAK3RET
SCHEMBL24539484	0.82	JAK2 (0.41)	JAK2JAK1TYK2JAK3RET
SCHEMBL29601621	0.81	JAK2 (0.41)	JAK2JAK1TYK2JAK3RET
SCHEMBL24328733	0.80	JAK2 (0.37)	JAK2JAK1TYK2JAK3RET
SCHEMBL29732784	0.80	FGFR3 (0.44)	JAK2JAK1TYK2JAK3RET
SCHEMBL24327398	0.79	JAK2 (0.39)	JAK2JAK1TYK2JAK3CNR1
SCHEMBL24539477	0.78	JAK2 (0.46)	JAK2JAK1TYK2JAK3RET
SCHEMBL29733004	0.78	MAPT (0.42)	JAK2JAK1TYK2JAK3RET
SCHEMBL24539407	0.77	JAK2 (0.45)	JAK2JAK1TYK2JAK3CNR1
SCHEMBL24539406	0.77	JAK2 (0.45)	JAK2JAK1TYK2JAK3CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022078356-A1	HETEROAROMATIC AHR INHIBITOR	山东轩竹医药科技有限公司	2022-04-21	—	—	WO	disclosed