Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525131 | 0.90 | HTR2C (0.45) | HTR2CL3MBTL1KDM1APARP1PARP2 | |
| SCHEMBL17524747 | 0.90 | HTR2C (0.45) | HTR2CL3MBTL1KDM1APARP1PARP2 | |
| Hydrochloric Acid SCHEMBL29236436 | 0.89 | HTR2C (0.46) | HTR2CL3MBTL1KDM1APARP1PARP2 | |
| Hydrochloric Acid SCHEMBL29236437 | 0.89 | HTR2C (0.46) | HTR2CL3MBTL1KDM1APARP1PARP2 | |
| SCHEMBL30859503 | 0.81 | HTR2C (0.40) | HTR2CL3MBTL1KDM1APARP1PARP2 | |
| SCHEMBL6177442 | 0.78 | HTR2C (0.53) | HTR2CL3MBTL1KDM1ALTA4H | |
| SCHEMBL19580349 | 0.78 | HTR2C (0.53) | HTR2CL3MBTL1KDM1ALTA4H | |
| SCHEMBL3597818 | 0.78 | HTR2C (0.53) | HTR2CL3MBTL1KDM1ALTA4H | |
| SCHEMBL24541088 | 0.78 | PRKACA (0.37) | HTR2CL3MBTL1METTL3 | |
| SCHEMBL7895312 | 0.77 | HTR2C (0.51) | HTR2CL3MBTL1KDM1ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194955-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | US | disclosed |
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194955-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | HTR2C 4792/4885L3MBTL1 1274/4885KDM1A 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.