Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 13/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65327 | 1.00 | TRPV4 (0.47) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2454255 | 1.00 | TRPV4 (0.47) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2458246 | 1.00 | TRPV4 (0.47) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2420763 | 0.86 | TRPV4 (0.47) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL65565 | 0.83 | CACNA1B (0.49) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL67623 | 0.81 | CACNA1B (0.50) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL67995 | 0.81 | CACNA1B (0.49) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL65932 | 0.81 | TRPV4 (0.45) | TRPV4MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL2419370 | 0.80 | CACNA1B (0.57) | MEN1ALDH1A1KMT2AL3MBTL1CACNA1B | |
| SCHEMBL16497951 | 0.80 | CACNA1B (0.57) | MEN1ALDH1A1KMT2AL3MBTL1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149995-A1 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA [C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | ABBOTT LABORATORIES (US) | 2011-12-01 | — | — | WO | disclosed |
| EP-2367790-A2 | SUBSTITUTED OCTAHYDROCYCLOPENTA(C)PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS | Abbott Laboratories (US) | 2011-09-28 | — | — | EP | disclosed |