SCHEMBL2454640

SCHEMBL2454640

N=C(CCC(=O)OC(=O)CCS)OC(=O)CCS

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.37
ACE P12821 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8519263 0.86 ALDH1A1 (0.37) ALDH1A1
SCHEMBL7712869 0.83 ALDH1A1 (0.50) ALDH1A1ACE
Ammonia Solution, Strong SCHEMBL28120022 0.80 ALDH1A1 (0.48) ALDH1A1ACE
SCHEMBL43574 0.79 EGLN1 (0.43) ALDH1A1ACE
SCHEMBL118947 0.79 ALDH1A1 (0.50) ALDH1A1
SCHEMBL876248 0.77 ALDH1A1 (0.37) ALDH1A1
SCHEMBL233404 0.77 ALDH1A1 (0.68) ALDH1A1
SCHEMBL1895096 0.77 ALDH1A1 (0.37) ALDH1A1
SCHEMBL3555482 0.77 ALDH1A1 (0.46) ALDH1A1
SCHEMBL27879493 0.76 ACE (0.54) ALDH1A1ACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11945848-B2 Chimeric inhibitor molecules of complement activation OMEROS CORPORATION (US) 2024-04-02 US disclosed
US-20230295252-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION OMEROS CORPORATION (US) 2023-09-21 US disclosed
US-11453709-B2 Chimeric inhibitor molecules of complement activation OMEROS CORPORATION (US) 2022-09-27 US disclosed
EP-3815708-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION Omeros Corporation (US) 2021-05-05 EP disclosed
US-20210009643-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION OMEROS CORPORATION (US) 2021-01-14 US disclosed
EP-2542569-B1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION OMEROS CORP (US) 2020-09-16 EP disclosed
US-10752661-B2 Chimeric inhibitor molecules of complement activation OMEROS CORPORATION (US) 2020-08-25 US disclosed
US-10294286-B2 Chimeric inhibitor molecules of complement activation OMEROS CORPORATION (US) 2019-05-21 US disclosed
US-20180273593-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION OMEROS CORPORATION (US) 2018-09-27 US disclosed
US-9815876-B2 Chimeric inhibitor molecules of complement activation OMEROS CORPORATION (US) 2017-11-14 US disclosed
US-20170166616-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION RIGSHOSPITALET (DK) 2017-06-15 US disclosed
US-9573984-B2 Chimeric inhibitor molecules of complement activation RIGSHOSPITALET (DK) 2017-02-21 US disclosed
US-20150210743-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION OMEROS CORPORATION 2015-07-30 US disclosed
US-20130217616-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION OMEROS CORPORATION 2013-08-22 US disclosed
EP-2542569-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION Rigshospitalet (DK) 2013-01-09 EP disclosed
WO-2011107591-A1 CHIMERIC INHIBITOR MOLECULES OF COMPLEMENT ACTIVATION RIGSHOSPITALET (DK) 2011-09-09 WO disclosed
US-20060105948-A1 GLP-2 derivatives NOVO NORDISK A/S (DK) 2006-05-18 US disclosed
EP-1608680-A2 GLP-2 DERIVATIVES NOVO NORDISK A/S (DK) 2005-12-28 EP disclosed
WO-2004085471-A2 GLP-2 DERIVATIVES NOVO NORDISK A/S (DK) 2004-10-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060105948-A1 GLP-2 derivatives GLP1R, GIPR, IAPP ALDH1A1 4668/4885ACE 2609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.