Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.60 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.33 |
| ▸ | PDE2A | O00408 | 8/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | PDE6D | O43924 | 1/20 | 0.30 |
| ▸ | PDE6A | P16499 | 1/20 | 0.30 |
| ▸ | PDE6G | P18545 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE6B | P35913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446366 | 0.99 | TRPM8 (0.61) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| SCHEMBL2455086 | 0.98 | TRPM8 (0.60) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| SCHEMBL2452068 | 0.90 | TRPM8 (0.73) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| SCHEMBL2445898 | 0.89 | TRPM8 (0.74) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| Hydrochloric Acid SCHEMBL2448734 | 0.89 | TRPM8 (0.73) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| SCHEMBL2445676 | 0.89 | TRPM8 (0.73) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| Potassium SCHEMBL2445679 | 0.89 | TRPM8 (0.73) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| SCHEMBL2452070 | 0.89 | TRPM8 (0.73) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| Trifluoroacetic Acid SCHEMBL2445440 | 0.84 | TRPM8 (0.64) | TRPM8PTGESL3MBTL1PDE10APDE2A | |
| SCHEMBL2450499 | 0.84 | TRPM8 (0.66) | TRPM8PTGESL3MBTL1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542552-B1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-15 | — | — | EP | disclosed |
| EP-2542552-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109587-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-09 | — | — | WO | disclosed |