Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455290 | 0.90 | GPR119 (0.54) | GPR119MCHR1NAMPT | |
| SCHEMBL2453005 | 0.89 | GPR119 (0.65) | GPR119MCHR1MAPTNAMPT | |
| SCHEMBL2453862 | 0.89 | GPR119 (0.55) | GPR119MCHR1MAPTNAMPT | |
| SCHEMBL2334675 | 0.87 | GPR119 (0.72) | GPR119POLBADRB2MAPTSMN1; SMN2 | |
| SCHEMBL2453010 | 0.87 | GPR119 (0.53) | GPR119MCHR1NAMPT | |
| SCHEMBL2456600 | 0.84 | GPR119 (0.58) | GPR119MCHR1 | |
| SCHEMBL2452869 | 0.83 | GPR119 (0.45) | GPR119MCHR1POLBADRB2MAPT | |
| SCHEMBL2450210 | 0.82 | GPR119 (0.78) | GPR119MCHR1 | |
| SCHEMBL2453856 | 0.81 | GPR119 (0.56) | GPR119MCHR1ADRB2 | |
| SCHEMBL2455123 | 0.81 | GPR119 (0.54) | GPR119MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170864-B1 | PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-14 | — | — | EP | claimed |