Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28093052 | 0.90 | CES1 (0.38) | NPC1RAB9ASMN1; SMN2L3MBTL1CES2 | |
| SCHEMBL8370038 | 0.82 | TSHR (0.48) | SMN1; SMN2CES2CES1ALOX15TSHR | |
| SCHEMBL28775846 | 0.81 | CES2 (0.59) | NPC1RAB9ASMN1; SMN2L3MBTL1CES2 | |
| SCHEMBL247590 | 0.81 | CES2 (0.59) | NPC1RAB9ASMN1; SMN2L3MBTL1CES2 | |
| SCHEMBL271808 | 0.80 | CES1 (0.54) | NPC1RAB9ASMN1; SMN2L3MBTL1CES2 | |
| SCHEMBL5672271 | 0.79 | PARP1 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1ALOX15 | |
| SCHEMBL28286804 | 0.78 | CES1 (0.52) | NPC1RAB9ASMN1; SMN2L3MBTL1CES2 | |
| SCHEMBL27658519 | 0.78 | PDCD1 (0.50) | NPC1RAB9ASMN1; SMN2L3MBTL1CES1 | |
| SCHEMBL28343283 | 0.77 | CES2 (0.54) | NPC1RAB9ASMN1; SMN2L3MBTL1CES2 | |
| SCHEMBL28101508 | 0.77 | HSD17B10 (0.50) | NPC1RAB9ASMN1; SMN2L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017628-B2 | Pharmaceutically active sulfonyl hydrazide derivatives | MERCK SERONO S.A. (CH) | 2011-09-13 | — | — | US | disclosed |
| US-20090005426-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-01-01 | — | — | US | disclosed |
| US-7432286-B1 | Pharmaceutically active sulfonyl hydrazide derivatives | LABORATORIES SERONO SA (CH) | 2008-10-07 | — | — | US | disclosed |
| EP-1216245-B1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS (AN) | 2004-05-26 | — | — | EP | disclosed |
| EP-1216245-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023382-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-05 | — | — | WO | disclosed |
| EP-1088822-A1 | Pharmaceutically active sulfonyl hydrazide derivatives | Applied Research Systems ARS Holding N.V. (AN) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005426-A1 | PHARMACEUTICALLY ACTIVE SULFONYL HYDRAZIDE DERIVATIVES | SLC5A1, SLC5A2, IAPP | NPC1 1482/4885RAB9A 520/4885SMN1; SMN2 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.