Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29638451 | 1.00 | TYK2 (0.39) | TYK2PLK1BTKPIK3C3TAAR1 | |
| SCHEMBL24557361 | 0.89 | MAPT (0.45) | TYK2PLK1FYNABCC1ABCG2 | |
| SCHEMBL29638328 | 0.89 | TYK2 (0.36) | TYK2BTKPIK3C3FYNABCC1 | |
| SCHEMBL29638464 | 0.89 | NPC1 (0.41) | TYK2BTKFYNALDH1A1MAPT | |
| SCHEMBL24557258 | 0.89 | NPC1 (0.41) | TYK2BTKFYNALDH1A1MAPT | |
| SCHEMBL29638398 | 0.87 | CDK4 (0.40) | TYK2FYNKDM4EMAPTGAA | |
| SCHEMBL24557308 | 0.87 | TYK2 (0.40) | TYK2PLK1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL29638404 | 0.87 | TYK2 (0.40) | TYK2PLK1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL24557356 | 0.86 | PHGDH (0.36) | TYK2PLK1JAK1 | |
| SCHEMBL24557357 | 0.85 | PLK1 (0.42) | TYK2PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |