Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24557258 | 1.00 | NPC1 (0.41) | NPC1RAB9AALDH1A1TP53LOX | |
| SCHEMBL29638414 | 0.90 | TYK2 (0.35) | TYK2GAAPOLBBTKLYN | |
| SCHEMBL29638452 | 0.89 | TYK2 (0.35) | TYK2GAALDHAPOLBBTK | |
| SCHEMBL24557360 | 0.89 | TYK2 (0.35) | TYK2GAALDHAPOLBBTK | |
| SCHEMBL24557361 | 0.89 | MAPT (0.45) | NPC1RAB9ATYK2GAAPOLB | |
| SCHEMBL29638437 | 0.89 | HPGD (0.40) | NPC1RAB9AALDH1A1TP53TYK2 | |
| SCHEMBL24557263 | 0.89 | TYK2 (0.39) | ALDH1A1TYK2GAAPOLBBTK | |
| SCHEMBL29638451 | 0.89 | TYK2 (0.39) | ALDH1A1TYK2GAAPOLBBTK | |
| SCHEMBL29638412 | 0.88 | AKR1C3 (0.44) | NPC1RAB9AALDH1A1TP53TYK2 | |
| SCHEMBL24557308 | 0.88 | TYK2 (0.40) | ALDH1A1TP53TYK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136914-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2022-06-30 | — | — | WO | disclosed |