Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | F7 | P08709 | 2/20 | 0.42 |
| ▸ | F3 | P13726 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20244269 | 1.00 | EPHX1 (0.50) | EPHX1ALDH1A1PPARAF7F3 | |
| SCHEMBL21105826 | 1.00 | EPHX1 (0.50) | EPHX1ALDH1A1PPARAF7F3 | |
| SCHEMBL8341644 | 0.94 | ALDH1A1 (0.52) | EPHX1ALDH1A1PPARAF7F3 | |
| SCHEMBL9212574 | 0.94 | ALDH1A1 (0.52) | EPHX1ALDH1A1PPARAF7F3 | |
| SCHEMBL18235465 | 0.90 | — | — | |
| SCHEMBL14178292 | 0.87 | EPHX1 (0.50) | EPHX1PPARAFAAHTRPV1 | |
| SCHEMBL14178224 | 0.87 | EPHX1 (0.48) | EPHX1PPARAL3MBTL1FAAHTRPV1 | |
| SCHEMBL21027713 | 0.86 | EPHX1 (0.71) | EPHX1PPARALPAR1FAAHTRPV1 | |
| SCHEMBL20621400 | 0.86 | EPHX1 (0.71) | EPHX1PPARALPAR1FAAHTRPV1 | |
| SCHEMBL23902967 | 0.86 | EPHX1 (0.71) | EPHX1PPARALPAR1FAAHTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999711-B1 | POLYMYXIN DERIVATIVES AND THEIR USE IN COMBINATION THERAPY TOGETHER WITH DIFFERENT ANTIBIOTICS | SPERO THERAPEUTICS INC (US) | 2022-06-29 | — | — | EP | disclosed |