Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.56 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24565689 | 1.00 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL24565690 | 1.00 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL447049 | 0.96 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL450027 | 0.96 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL447762 | 0.96 | CHRNB4 (0.60) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL13867982 | 0.82 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL15037237 | 0.82 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL25594625 | 0.82 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL15032896 | 0.82 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL6521793 | 0.82 | CHRNB1 (0.45) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |