Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | RHOC | P08134 | 3/20 | 0.46 |
| ▸ | RHOA | P61586 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24566548 | 0.93 | RHOA (0.44) | MRGPRX4HIF1ARHOCRHOAKDM4E | |
| SCHEMBL24567221 | 0.93 | RHOA (0.44) | MRGPRX4HIF1ARHOCRHOAKDM4E | |
| SCHEMBL24566608 | 0.87 | PDK2 (0.46) | HIF1ARHOCRHOAKDM4EUSP2 | |
| SCHEMBL4280019 | 0.84 | RHOC (0.50) | HIF1ARHOCRHOAKDM4EGAA | |
| SCHEMBL4929358 | 0.81 | KDM4E (0.65) | HIF1AKDM4EUSP2CYP3A4TSHR | |
| SCHEMBL13243072 | 0.81 | KDM4E (0.70) | HIF1AKDM4EUSP2CYP3A4TSHR | |
| SCHEMBL1265003 | 0.80 | HIF1A (0.63) | HIF1ARHOCRHOAKDM4EUSP2 | |
| SCHEMBL13243068 | 0.80 | RHOA (0.47) | MRGPRX4HIF1ARHOCRHOAKDM4E | |
| SCHEMBL13243066 | 0.80 | RHOA (0.47) | MRGPRX4HIF1ARHOCRHOAKDM4E | |
| SCHEMBL24567241 | 0.79 | PDK2 (0.50) | HIF1ARHOCRHOAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |