Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24565775 | 0.84 | KCNJ6 (0.41) | SMN1; SMN2KDM4EMITFALDH1A1HPGD | |
| SCHEMBL24007634 | 0.73 | KDM4E (0.44) | SMN1; SMN2KDM4EMITFALDH1A1HPGD | |
| SCHEMBL799063 | 0.69 | PPARA (0.47) | SMN1; SMN2ALDH1A1NR3C1NPSR1GAA | |
| SCHEMBL11899889 | 0.69 | GRN (0.73) | KDM4EALDH1A1NPSR1GAAGRN | |
| SCHEMBL25594884 | 0.68 | PPARA (0.45) | NR3C1JAK2PTGER1CYP2C9HDAC3 | |
| SCHEMBL25599482 | 0.67 | PPARA (0.44) | NR3C1JAK2PTGER1CYP2C9 | |
| SCHEMBL24007902 | 0.67 | KDM4E (0.41) | SMN1; SMN2KDM4EMITFALDH1A1HPGD | |
| SCHEMBL798561 | 0.66 | GRN (0.49) | ALDH1A1TDP1NR3C1GAAGRN | |
| SCHEMBL20661034 | 0.66 | HPGD (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDNR3C1 | |
| SCHEMBL799021 | 0.66 | GAA (0.44) | SMN1; SMN2ALDH1A1HPGDTDP1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |