Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 6/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 6/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 6/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24565774 | 0.84 | SMN1; SMN2 (0.43) | CFTRJAK2HDAC3HDAC4HDAC1 | |
| SCHEMBL24565772 | 0.78 | LTA4H (0.37) | KCNJ6KCNJ5KCNJ3MAPK14HDAC3 | |
| SCHEMBL24565773 | 0.77 | NAAA (0.37) | KCNJ6KCNJ5KCNJ3MAPK14HDAC3 | |
| SCHEMBL24007637 | 0.75 | ADORA1 (0.46) | KDM4EMITFALDH1A1HPGDKLF5 | |
| SCHEMBL24007919 | 0.70 | TMIGD3 (0.43) | KDM4EMITFALDH1A1HPGDKLF5 | |
| SCHEMBL24008156 | 0.70 | TMIGD3 (0.35) | KCNJ6KCNJ5KCNJ3KDM4EMITF | |
| SCHEMBL11899889 | 0.66 | GRN (0.73) | MAPK14KDM4EALDH1A1 | |
| SCHEMBL24567211 | 0.65 | TMIGD3 (0.39) | — | |
| SCHEMBL24567226 | 0.65 | TMIGD3 (0.39) | — | |
| SCHEMBL799063 | 0.65 | PPARA (0.47) | KCNJ6KCNJ5KCNJ3MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |