Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | FLT1 | P17948 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | CLK2 | P49760 | 4/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.47 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.47 |
| ▸ | PAK4 | O96013 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253533 | 0.77 | KDR (0.62) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL30826139 | 0.76 | DAO (0.41) | ALDH1A1 | |
| SCHEMBL15785416 | 0.76 | PARP1 (0.37) | — | |
| SCHEMBL29219201 | 0.76 | DAO (0.41) | ALDH1A1 | |
| SCHEMBL14820336 | 0.72 | KDM4E (0.33) | KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL10131569 | 0.71 | DYRK1A (0.46) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL11379147 | 0.69 | PDE3B (0.54) | PDGFRANTRK1METPDGFRBGSK3A | |
| SCHEMBL6530784 | 0.69 | PARP1 (0.57) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL14805792 | 0.68 | KDM4E (0.37) | KDM4EHSD17B10KMT2A | |
| SCHEMBL10131568 | 0.68 | AURKA (0.47) | DYRK1ADYRK1BAURKAJAK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| CN-111393433-B | Heterocyclic benzene sulfonamide compound and application thereof | 暨南大学 | 2021-07-30 | — | — | CN | disclosed |
| CN-111393433-A | Heterocyclic benzene sulfonamide compound and application thereof | 暨南大学 | 2020-07-10 | — | — | CN | disclosed |