Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | PDXK | O00764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24566629 | 0.77 | — | — | |
| SCHEMBL25240328 | 0.73 | — | — | |
| SCHEMBL27657505 | 0.72 | AAK1 (0.38) | DRD2DRD4DRD3PDXK | |
| SCHEMBL24566632 | 0.70 | DRD2 (0.36) | DRD2DRD4DRD3 | |
| SCHEMBL24566626 | 0.67 | DRD2 (0.50) | DRD2DRD4DRD3 | |
| SCHEMBL25757242 | 0.67 | DRD4 (0.39) | DRD2DRD4DRD3 | |
| SCHEMBL30430837 | 0.66 | DRD3 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL30431370 | 0.66 | DRD3 (0.50) | DRD2DRD4DRD3 | |
| SCHEMBL24566314 | 0.66 | DRD2 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL24567045 | 0.65 | MAPK14 (0.44) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |