Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460219 | 0.98 | CCR2 (0.46) | CCR2CCR5ENPP1NR3C1NR3C2 | |
| SCHEMBL2456565 | 0.96 | CCR2 (0.50) | CCR2CCR5ENPP1NR3C1NR3C2 | |
| SCHEMBL2457070 | 0.91 | CCR2 (0.44) | CCR2CCR5ENPP1NR3C1NR3C2 | |
| SCHEMBL2462973 | 0.89 | CCR2 (0.39) | CCR2CCR5PDE2APLATADORA1 | |
| SCHEMBL2456675 | 0.86 | CCR2 (0.41) | CCR2CCR5ENPP1NR3C1NR3C2 | |
| SCHEMBL2456672 | 0.86 | CCR2 (0.41) | CCR2CCR5ENPP1NR3C1NR3C2 | |
| SCHEMBL2455160 | 0.86 | CCR2 (0.43) | CCR2ENPP1NR3C1PDE2APDE1B | |
| SCHEMBL2460011 | 0.86 | CCR2 (0.43) | CCR2CCR5NR3C1PDE2A | |
| SCHEMBL2457418 | 0.84 | CCR2 (0.42) | CCR2CCR5NR3C1PDE2APLAT | |
| SCHEMBL2454681 | 0.84 | PDE2A (0.44) | CCR2CCR5NR3C1PGRPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |