Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | BRD2 | P25440 | 1/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | FABP6 | P51161 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27710864 | 0.89 | CA1 (0.51) | BRD4BRD2BRD3BRDTCA1 | |
| SCHEMBL2463599 | 0.87 | KDM4E (0.57) | BRD4BRD2BRD3BRDTCA1 | |
| SCHEMBL14884675 | 0.84 | BRD4 (0.57) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL1617368 | 0.82 | BRD4 (0.70) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL5436912 | 0.81 | SDHB (0.47) | BRD4BRD2BRD3BRDTNPC1 | |
| SCHEMBL2458827 | 0.81 | CMA1 (0.51) | CHRM1ALDH1A1LMNACMA1HDAC11 | |
| SCHEMBL5437262 | 0.80 | CA1 (0.53) | CA1CA2NPC1POLBRAB9A | |
| SCHEMBL7229327 | 0.79 | BRD4 (0.59) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL5445065 | 0.79 | SDHB (0.54) | SMN1; SMN2NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8276905 | 0.79 | CMA1 (0.53) | NPC1POLBRAB9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791147-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. | 2011-09-22 | — | — | US | disclosed |
| WO-2010042642-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230517-A1 | CALCIUM RECEPTOR MODULATING AGENTS | CASR, CALCR, CNR1 | BRD4 1462/4885BRD2 1789/4885BRD3 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.