Sugi Predict

Sugi Predict / Compounds / SCHEMBL2456845

SCHEMBL2456845

SCHEMBL2456845

N[N+]12C=CN=CC1=C(C1CCC(C(=O)N3CCC(CO)CC3)CC1)N=C2c1cccc(OCc2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 8/20 0.45
▸ KDM4E B2RXH2 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ HTT P42858 1/20 0.40
▸ PLAT P00750 1/20 0.37
▸ F10 P00742 2/20 0.37
▸ JAK2 O60674 1/20 0.37
▸ JAK1 P23458 1/20 0.37
▸ TP53 P04637 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ LTB4R Q15722 1/20 0.36
▸ LTB4R2 Q9NPC1 1/20 0.36
▸ BTK Q06187 1/20 0.35
▸ SPHK2 Q9NRA0 1/20 0.35
▸ MCHR1 Q99705 1/20 0.35
▸ MGLL Q99685 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2463107 0.93 IGF1R (0.46) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2459771 0.93 IGF1R (0.51) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2460493 0.93 IGF1R (0.52) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2459610 0.92 IGF1R (0.53) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2459666 0.92 IGF1R (0.53) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2459717 0.92 IGF1R (0.45) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2459618 0.91 IGF1R (0.46) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2461612 0.91 IGF1R (0.46) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2457081 0.90 IGF1R (0.44) IGF1RKDM4EALDH1A1LMNAHTT
SCHEMBL2460257 0.90 IGF1R (0.40) IGF1RPLATSPHK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP claimed
US-7459554-B2 Imidazopyrazine tyrosine kinase inhibitors OSI PHARMACEUTICALS, INC. (US) 2008-12-02 — — US claimed
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS BECK PATRICIA A 2008-09-18 — — US claimed
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors ACERTA PHARMA B.V. (NL) 2006-04-20 — — US claimed
EP-1675860-B1 IMIDAZO[1,5-A]PYRAZINES AS TYROSINE KINASE INHIBITORS OSI PHARM INC (US) 2011-09-21 — — EP disclosed
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors OSI PHARMACEUTICALS, INC. 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080227788-A9 IMIDAZOPYRAZINE TYROSINE KINASE INHIBITORS IGF1R, IRS1, IGFBP1 IGF1R 1/4885KDM4E 1461/4885ALDH1A1 703/4885
US-20060084654-A1 Imidazopyrazine tyrosine kinase inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885KDM4E 1461/4885ALDH1A1 703/4885
US-20090181940-A1 Imidazopyrazine Tyrosine Kinase Inhibitors IGF1R, IRS1, IGFBP1 IGF1R 1/4885KDM4E 1461/4885ALDH1A1 703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.