Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24747145 | 1.00 | HSD17B10 (0.43) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL5518371 | 0.91 | CYP1A2 (0.48) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL4550437 | 0.83 | CYP3A4 (0.43) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL23817652 | 0.81 | EPHX2 (0.47) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL14297361 | 0.78 | SMN1; SMN2 (0.43) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL18478135 | 0.78 | SMN1; SMN2 (0.43) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL18478136 | 0.78 | SMN1; SMN2 (0.43) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL23817654 | 0.78 | CYP1A2 (0.40) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL23145122 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ATDP1SMN1; SMN2 | |
| SCHEMBL24962059 | 0.76 | FFAR3 (0.48) | HSD17B10ALDH1A1CYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022137082-A1 | PYRROLO[3,2-B]PYRIDINE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS | NOVARTIS AG (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022137085-A1 | INDOLE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS | NOVARTIS AG (CH) | 2022-06-30 | — | — | WO | disclosed |