Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 10/20 | 0.45 |
| ▸ | EGFR | P00533 | 10/20 | 0.45 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888029 | 1.00 | ERBB2 (0.45) | ERBB2EGFRGCKMKNK1MKNK2 | |
| SCHEMBL29887989 | 0.93 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL29887758 | 0.93 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL24569813 | 0.93 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL24569620 | 0.93 | ERBB2 (0.52) | ERBB2EGFR | |
| SCHEMBL24569327 | 0.92 | EGFR (0.45) | ERBB2EGFR | |
| SCHEMBL29887975 | 0.92 | EGFR (0.45) | ERBB2EGFR | |
| SCHEMBL24569300 | 0.91 | EGFR (0.42) | ERBB2EGFRMKNK2 | |
| SCHEMBL29888017 | 0.90 | ERBB2 (0.49) | ERBB2EGFR | |
| SCHEMBL24569344 | 0.89 | ERBB2 (0.42) | ERBB2EGFRGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116921-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN INC. | 2024-04-11 | — | — | US | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116921-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ERBB2, FGFR2, ERBB3 | ERBB2 1/4885EGFR 5/4885GCK 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.