Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.45 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.39 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29887975 | 1.00 | EGFR (0.45) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL29887758 | 0.93 | ERBB2 (0.52) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL29887989 | 0.93 | ERBB2 (0.52) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL24569813 | 0.93 | ERBB2 (0.52) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL24569620 | 0.93 | ERBB2 (0.52) | EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL24569308 | 0.92 | ERBB2 (0.45) | EGFRERBB2 | |
| SCHEMBL29888029 | 0.92 | ERBB2 (0.45) | EGFRERBB2 | |
| SCHEMBL24569300 | 0.91 | EGFR (0.42) | EGFRERBB2ERBB4 | |
| SCHEMBL29888017 | 0.90 | ERBB2 (0.49) | EGFRERBB2 | |
| SCHEMBL29888139 | 0.89 | ERBB2 (0.47) | EGFRERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |