Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888033 | 1.00 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL24569510 | 1.00 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL29888024 | 0.83 | MEN1 (0.38) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL29888051 | 0.83 | MEN1 (0.38) | PDE4APDE4BPDE4CPDE4DHSD17B10 | |
| SCHEMBL25970732 | 0.80 | HSD17B10 (0.45) | HSD17B10NPC1UCHL1ALDH1A1MEN1 | |
| SCHEMBL25970778 | 0.80 | HSD17B10 (0.45) | HSD17B10NPC1UCHL1ALDH1A1MEN1 | |
| SCHEMBL25971820 | 0.80 | HSD17B10 (0.45) | HSD17B10NPC1UCHL1ALDH1A1MEN1 | |
| SCHEMBL9387477 | 0.79 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL20256229 | 0.79 | HSD17B10 (0.49) | HSD17B10NPC1UCHL1ALDH1A1MEN1 | |
| SCHEMBL22139321 | 0.79 | HSD17B10 (0.49) | HSD17B10NPC1UCHL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267137-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |