Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888051 | 1.00 | MEN1 (0.38) | MEN1KMT2AHSD17B10NR1H2NR1H3 | |
| SCHEMBL24569510 | 0.83 | PDE4A (0.42) | MEN1KMT2AHSD17B10PDE4APDE4B | |
| SCHEMBL29888033 | 0.83 | PDE4A (0.42) | MEN1KMT2AHSD17B10PDE4APDE4B | |
| SCHEMBL24569508 | 0.83 | PDE4A (0.42) | MEN1KMT2AHSD17B10PDE4APDE4B | |
| SCHEMBL29887877 | 0.81 | GPR119 (0.38) | NR1H2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29504630 | 0.74 | NR1H3 (0.40) | MEN1KMT2AHSD17B10NR1H2NR1H3 | |
| SCHEMBL24569886 | 0.71 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27193620 | 0.71 | KDM1A (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL31556668 | 0.71 | PDE4A (0.43) | MEN1KMT2AHSD17B10PDE4APDE4B | |
| SCHEMBL9387477 | 0.70 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267137-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |