Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24569555 | 1.00 | DDB1 (0.32) | DDB1CRBNBUB1GPR119KDM1A | |
| SCHEMBL29887993 | 1.00 | DDB1 (0.32) | DDB1CRBNBUB1GPR119KDM1A | |
| SCHEMBL8276859 | 0.78 | BUB1 (0.35) | DDB1CRBNBUB1KDM1A | |
| SCHEMBL24570203 | 0.77 | BUB1 (0.31) | BUB1 | |
| SCHEMBL24569539 | 0.77 | KDM1A (0.33) | DDB1CRBNBUB1KDM1A | |
| SCHEMBL24570324 | 0.77 | KDM1A (0.33) | DDB1CRBNBUB1KDM1A | |
| SCHEMBL17459688 | 0.76 | BRD4 (0.35) | BUB1 | |
| SCHEMBL17459686 | 0.76 | BRD4 (0.35) | BUB1 | |
| SCHEMBL24569725 | 0.73 | BUB1 (0.35) | DDB1CRBNBUB1KDM1A | |
| SCHEMBL24570043 | 0.72 | BUB1 (0.35) | DDB1CRBNBUB1GPR119KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |