Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.33 |
| ▸ | RELA | Q04206 | 4/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17459688 | 1.00 | BRD4 (0.35) | BRD4NFKB1NFKB2RELACYP11B2 | |
| SCHEMBL17459703 | 0.79 | INMT (0.33) | SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL17459701 | 0.79 | INMT (0.33) | SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4621580 | 0.79 | USP2 (0.40) | BRD4CTSKUSP2SMN1; SMN2BUB1 | |
| SCHEMBL17459694 | 0.76 | SMN1; SMN2 (0.38) | NFKB1NFKB2RELASMN1; SMN2HTT | |
| SCHEMBL24569555 | 0.76 | DDB1 (0.32) | BUB1 | |
| SCHEMBL29887993 | 0.76 | DDB1 (0.32) | BUB1 | |
| SCHEMBL24569558 | 0.76 | DDB1 (0.32) | BUB1 | |
| SCHEMBL13617428 | 0.75 | ESR2 (0.37) | BRD4CYP11B2CTSKUSP2SMN1; SMN2 | |
| SCHEMBL21348242 | 0.74 | USP2 (0.34) | BRD4CTSKUSP2SMN1; SMN2PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10758524-B2 | Compositions and methods for selectively depleting senescent cells | BIOVENTURES, LLC (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180369223-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-12-27 | — | — | US | disclosed |
| US-10071087-B2 | Compositions and methods for selectively depleting senescent cells | BIOVENTURES, LLC (US) | 2018-09-11 | — | — | US | disclosed |
| US-20170246155-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | BIOVENTURES, LLC | 2017-08-31 | — | — | US | disclosed |
| EP-3177144-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | Bioventures, LLC. (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2016014625-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (US) | 2016-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10071087-B2 | Compositions and methods for selectively depleting senescent cells | CD47, MCL1, LIMS1 | BRD4 1552/4885NFKB1 428/4885NFKB2 564/4885 |
| US-10758524-B2 | Compositions and methods for selectively depleting senescent cells | CD47, MCL1, LIMS1 | BRD4 1552/4885NFKB1 428/4885NFKB2 564/4885 |
| US-20170246155-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | CD47, MCL1, LIMS1 | BRD4 1552/4885NFKB1 428/4885NFKB2 564/4885 |
| US-20180369223-A1 | COMPOSITIONS AND METHODS FOR SELECTIVELY DEPLETING SENESCENT CELLS | CD47, MCL1, LIMS1 | BRD4 1552/4885NFKB1 428/4885NFKB2 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.