Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FECH | P22830 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.45 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888324 | 0.91 | ERBB2 (0.52) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL12888316 | 0.91 | EGFR (0.52) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL12888225 | 0.90 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL24167726 | 0.90 | ERBB2 (0.53) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL12888153 | 0.90 | ERBB2 (0.56) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL12872671 | 0.89 | ERBB2 (0.53) | EGFRERBB2FECHNQO2MYH14 | |
| SCHEMBL12888163 | 0.89 | ERBB2 (0.50) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL12888313 | 0.88 | ERBB2 (0.49) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL12888198 | 0.88 | ERBB2 (0.53) | EGFRERBB2FECHNQO2MYH14 | |
| SCHEMBL25429034 | 0.88 | ERBB2 (0.53) | EGFRERBB2MAPTFECHCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |