SCHEMBL25429034

SCHEMBL25429034

Cc1cc(Nc2ncnc3ccc(O)cc23)ccc1Oc1ccc2c(c1)ncn2C

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERBB2 P04626 10/20 0.53
EGFR P00533 13/20 0.52
FECH P22830 2/20 0.45
NQO2 P16083 1/20 0.45
MYH14 Q7Z406 1/20 0.45
RIPK3 Q9Y572 1/20 0.45
ERBB3 P21860 1/20 0.44
ERBB4 Q15303 1/20 0.44
RAF1 P04049 2/20 0.43
BRAF P15056 2/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CDK8 P49336 1/20 0.43
MAP2K5 Q13163 1/20 0.43
CDK19 Q9BWU1 1/20 0.43
MKNK2 Q9HBH9 1/20 0.43
HDAC1 Q13547 2/20 0.43
HDAC6 Q9UBN7 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30576206 1.00 ERBB2 (0.53) ERBB2EGFRFECHNQO2MYH14
SCHEMBL24569430 0.91 MAPT (0.55) ERBB2EGFRFECHNQO2MYH14
SCHEMBL12872592 0.90 EGFR (0.54) ERBB2EGFRERBB3ERBB4RAF1
SCHEMBL12873044 0.90 MAPT (0.55) ERBB2EGFRFECHNQO2MYH14
SCHEMBL29887863 0.89 ERBB2 (0.53) ERBB2EGFRFECHNQO2MYH14
SCHEMBL24569429 0.89 ERBB2 (0.53) ERBB2EGFRFECHNQO2MYH14
SCHEMBL24569726 0.88 EGFR (0.53) ERBB2EGFRFECHNQO2MYH14
SCHEMBL1192984 0.86 ERBB2 (0.54) ERBB2EGFRFECHNQO2MYH14
SCHEMBL12872950 0.86 ERBB2 (0.51) ERBB2EGFRFECHNQO2MYH14
SCHEMBL12888316 0.86 EGFR (0.52) ERBB2EGFRFECHERBB4CDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023154124-A1 ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN THERAPEUTICS, INC. (US) 2023-08-17 WO disclosed
WO-2023154124-A1 ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN THERAPEUTICS, INC. (US) 2023-08-17 WO disclosed