Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 10/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | FECH | P22830 | 1/20 | 0.48 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24569385 | 0.92 | EGFR (0.49) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL24167890 | 0.92 | EGFR (0.48) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL29888850 | 0.92 | EGFR (0.49) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL29887887 | 0.91 | EGFR (0.47) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL29888075 | 0.91 | EGFR (0.47) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL24569409 | 0.91 | EGFR (0.47) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL24167630 | 0.87 | MAPT (0.51) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL26008684 | 0.87 | EGFR (0.44) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL25432467 | 0.86 | EGFR (0.45) | HTTMAPTLMNASMN1; SMN2EGFR | |
| SCHEMBL25432434 | 0.86 | EGFR (0.45) | HTTMAPTLMNASMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |