Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | FECH | P22830 | 1/20 | 0.49 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.49 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29888850 | 1.00 | EGFR (0.49) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24569870 | 0.92 | HTT (0.55) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24167890 | 0.91 | EGFR (0.48) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL29888075 | 0.90 | EGFR (0.47) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL29887887 | 0.90 | EGFR (0.47) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24569409 | 0.90 | EGFR (0.47) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL29888339 | 0.86 | KDM4E (0.53) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24569376 | 0.86 | KDM4E (0.53) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL24167630 | 0.86 | MAPT (0.51) | EGFRERBB2NQO2FECHMYH14 | |
| SCHEMBL26008684 | 0.86 | EGFR (0.44) | EGFRERBB2NQO2FECHMYH14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |