Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | USP2 | O75604 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453800 | 0.88 | MAPT (0.60) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL2454605 | 0.85 | MAPT (0.68) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL27713986 | 0.84 | MAPT (0.54) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL2458222 | 0.82 | MAPT (0.62) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL5183437 | 0.82 | NPC1 (0.62) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL4414247 | 0.81 | HDAC8 (0.77) | MAPTTP53MAPK1LMNARAB9A | |
| SCHEMBL20456242 | 0.81 | CTSL (0.51) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL1476346 | 0.80 | MAPT (0.62) | MAPTUSP2TP53MAPK1HSD17B10 | |
| SCHEMBL1663341 | 0.78 | HDAC8 (0.71) | MAPTTP53MAPK1LMNARAB9A | |
| SCHEMBL18745963 | 0.78 | HDAC8 (0.71) | MAPTTP53MAPK1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-20090069344-A1 | Modulators of hcv replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069344-A1 | Modulators of hcv replication | EIF2AK2, IRF3, IFNAR1 | MAPT 4662/4885USP2 2202/4885TP53 2984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.