Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 9/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP1 | P63208 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24574069 | 0.90 | EIF2AK4 (0.42) | EIF2AK4FLT3USP30CKS1BSKP1 | |
| SCHEMBL24574426 | 0.88 | FLT3 (0.40) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24574187 | 0.87 | FLT3 (0.45) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24573972 | 0.87 | FLT3 (0.49) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24574188 | 0.87 | FLT3 (0.45) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24574508 | 0.87 | FLT3 (0.40) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24574507 | 0.87 | FLT3 (0.40) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24574510 | 0.86 | FLT3 (0.46) | EIF2AK4FLT3USP30IRAK4 | |
| SCHEMBL24574153 | 0.86 | FLT3 (0.49) | EIF2AK4FLT3USP30IRAK4CCNT1 | |
| SCHEMBL24574583 | 0.86 | FLT3 (0.44) | EIF2AK4FLT3USP30IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612410-B2 | Multi-cyclic IRAK and FLT3 inhibiting compounds and uses thereof | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2026-04-28 | — | — | US | disclosed |
| US-20240294530-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER | 2024-09-05 | — | — | US | disclosed |
| EP-4267142-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140647-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022140647-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2022-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294530-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | FLT3, IRAK1, IRAK2 | EIF2AK4 803/4885FLT3 1/4885USP30 1732/4885 |
| US-12612410-B2 | Multi-cyclic IRAK and FLT3 inhibiting compounds and uses thereof | FLT3, IRAK3, IRAK2 | EIF2AK4 716/4885FLT3 1/4885USP30 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.