Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATXN2 | Q99700 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 6/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31119103 | 1.00 | ATXN2 (0.45) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23499431 | 0.88 | JAK1 (0.40) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23499428 | 0.88 | JAK1 (0.40) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23499430 | 0.88 | JAK1 (0.40) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23499425 | 0.84 | JAK1 (0.42) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23499427 | 0.84 | JAK1 (0.42) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL29919210 | 0.84 | AURKA (0.42) | JAK1AURKAPIK3CDPIK3CAPIK3R1 | |
| SCHEMBL23933530 | 0.84 | JAK1 (0.41) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23933533 | 0.84 | JAK1 (0.41) | ATXN2JAK1AURKAPIK3CDPIK3CA | |
| SCHEMBL23499423 | 0.84 | JAK1 (0.36) | ATXN2JAK1AURKAAURKBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102100-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2023-06-08 | — | — | WO | disclosed |
| WO-2022140499-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-06-30 | — | — | WO | disclosed |