Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 3/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759536 | 1.00 | PDGFRA (0.67) | PDGFRACHRM1HRH3KITFASN | |
| SCHEMBL30809551 | 0.92 | PDGFRA (0.57) | PDGFRACHRM1HRH3KITFASN | |
| SCHEMBL29760153 | 0.89 | PDGFRA (0.54) | PDGFRACHRM1HRH3KITIRAK4 | |
| SCHEMBL24577090 | 0.89 | PDGFRA (0.54) | PDGFRACHRM1HRH3KITIRAK4 | |
| SCHEMBL24577877 | 0.89 | PDGFRA (0.73) | PDGFRACHRM1HRH3KITIRAK4 | |
| SCHEMBL29759503 | 0.89 | PDGFRA (0.73) | PDGFRACHRM1HRH3KITIRAK4 | |
| SCHEMBL24577956 | 0.88 | PDGFRA (0.64) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL29760038 | 0.88 | PDGFRA (0.64) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL29760108 | 0.88 | PDGFRA (0.62) | PDGFRACHRM1HRH3KITIRAK4 | |
| SCHEMBL24577235 | 0.88 | PDGFRA (0.64) | PDGFRACHRM1HRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |