Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577090 | 1.00 | PDGFRA (0.54) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL29759536 | 0.89 | PDGFRA (0.67) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL24576833 | 0.89 | PDGFRA (0.67) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL24577274 | 0.89 | PDGFRA (0.48) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL29759496 | 0.89 | PDGFRA (0.60) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL24577037 | 0.89 | PDGFRA (0.60) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL29760161 | 0.88 | PDGFRA (0.46) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL30809551 | 0.81 | PDGFRA (0.57) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL29759622 | 0.81 | BDKRB1 (0.36) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL24577421 | 0.81 | CHRM1 (0.40) | PDGFRACHRM1HRH3IRAK4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267585-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |