Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.30 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759441 | 1.00 | PDGFRA (0.47) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL24577614 | 0.89 | PDGFRA (0.54) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL29759498 | 0.89 | PDGFRA (0.54) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL29759448 | 0.88 | PDGFRA (0.46) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL24577274 | 0.87 | PDGFRA (0.48) | PDGFRACHRM1HRH3IRAK4CSF1R | |
| SCHEMBL24576811 | 0.86 | PDGFRA (0.65) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL29759428 | 0.86 | PDGFRA (0.65) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL29759626 | 0.85 | PDGFRA (0.47) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577231 | 0.84 | PDGFRA (0.45) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759669 | 0.84 | PDGFRA (0.45) | PDGFRACHRM1HRH3CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |