Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CSK | P41240 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759669 | 1.00 | PDGFRA (0.45) | PDGFRACHRM1HRH3KDRMALT1 | |
| SCHEMBL24578251 | 0.88 | KDR (0.37) | PDGFRAKDRMALT1CSF1RKIT | |
| SCHEMBL29759572 | 0.87 | PDGFRA (0.60) | PDGFRACHRM1HRH3KDRKIT | |
| SCHEMBL24577277 | 0.87 | PDGFRA (0.60) | PDGFRACHRM1HRH3KDRKIT | |
| SCHEMBL29759448 | 0.85 | PDGFRA (0.46) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577289 | 0.85 | KDR (0.34) | PDGFRACHRM1HRH3KDRMALT1 | |
| SCHEMBL29760036 | 0.85 | KDR (0.34) | PDGFRACHRM1HRH3KDRMALT1 | |
| SCHEMBL24577614 | 0.84 | PDGFRA (0.54) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759498 | 0.84 | PDGFRA (0.54) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24576954 | 0.84 | PDGFRA (0.47) | PDGFRACHRM1HRH3MALT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |