Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 9/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | F9 | P00740 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577471 | 0.84 | BACE1 (0.40) | KDM5BJAK2FEN1NTRK1PIK3CA | |
| SCHEMBL24577209 | 0.82 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL24577874 | 0.80 | FLT3 (0.38) | KITJAK2JAK1TYK2PIK3CA | |
| SCHEMBL30566490 | 0.80 | PDK2 (0.41) | KITPDK2KDM5BJAK2JAK1 | |
| SCHEMBL24579168 | 0.76 | KIT (0.43) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL29759768 | 0.72 | IKBKE (0.42) | KITJAK2TYK2MAP4K4NTRK1 | |
| Hydrochloric Acid SCHEMBL30566540 | 0.72 | IKBKE (0.42) | KITJAK2TYK2MAP4K4NTRK1 | |
| Hydrochloric Acid SCHEMBL27185082 | 0.72 | IKBKE (0.42) | KITJAK2TYK2MAP4K4NTRK1 | |
| SCHEMBL24578878 | 0.71 | KDR (0.38) | TGFBR1 | |
| SCHEMBL24578525 | 0.70 | BRAF (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |