Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24577085 | 0.84 | KIT (0.39) | KDM5BFEN1NTRK1PIK3CAJAK2 | |
| SCHEMBL24577992 | 0.82 | IKBKE (0.42) | BACE1KDM5BFEN1IKBKETBK1 | |
| SCHEMBL24576990 | 0.81 | IKBKE (0.41) | BACE1KDM5BFEN1IKBKETBK1 | |
| SCHEMBL24577874 | 0.78 | FLT3 (0.38) | PIK3CDPIK3CAPIK3CGJAK2 | |
| SCHEMBL24577209 | 0.75 | JAK2 (0.39) | JAK2 | |
| SCHEMBL29759699 | 0.73 | IKBKE (0.48) | BACE1FEN1IKBKETBK1KAT5 | |
| SCHEMBL29760255 | 0.72 | IKBKE (0.44) | BACE1IKBKETBK1KAT5 | |
| Hydrochloric Acid SCHEMBL29759717 | 0.72 | IKBKE (0.47) | BACE1FEN1IKBKETBK1KAT5 | |
| SCHEMBL24579168 | 0.69 | KIT (0.43) | KDM5BJAK2 | |
| SCHEMBL24578878 | 0.69 | KDR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022136509-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2022-06-30 | — | — | WO | disclosed |